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5-HT1A receptor sensitivity in major depression. A neuroendocrine study with buspirone.

Abstract:

The hypothermic, growth hormone and corticotrophin (ACTH) responses to the 5-HT1A receptor agonist buspirone (30 mg orally) were measured in 20 unmedicated patients with major depression and 20 healthy controls. Compared with the controls, the hypothermic responses of the depressed patients to buspirone were significantly attenuated, particularly in patients with melancholic depression. In contrast, the responses of growth hormone and ACTH to buspirone were unchanged. The data suggest that ma...

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Publication status:
Published

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Publisher copy:
10.1192/bjp.164.3.372

Authors


Anderson, IM More by this author
Journal:
The British journal of psychiatry : the journal of mental science
Volume:
164
Issue:
3
Pages:
372-379
Publication date:
1994-03-05
DOI:
EISSN:
1472-1465
ISSN:
0007-1250
URN:
uuid:3c24778c-b271-4632-bb7e-c6f6d0e76356
Source identifiers:
186008
Local pid:
pubs:186008

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