Effects of vaccinia virus anti-inflammatory protein 35K and TIMP-1 gene transfers on vein graft stenosis in rabbits.

Puhakka, HL; Turunen, P; Gruchala, M; Bursill, C; Heikura, T; Vajanto, I; Greaves, DR; Channons, K; Ylä-Herttuala, S

Abstract:

BACKGROUND: Vein graft stenosis is a common problem after bypass surgery. Vein grafts are ideal targets for gene therapy because transduction can be made ex vivo before grafting. Since chemokines and inflammatory factors are involved in vein graft thickening, we tested a hypothesis that the vaccinia virus anti-inflammatory protein 35K which can sequester CC-chemokines, can reduce vein graft thickening in vivo. MATERIALS AND METHODS: We used adenovirus-mediated gene transfer (1x10(9) pfu/ml) ...

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APA Style

Puhakka, H. L., Turunen, P., Gruchala, M., Bursill, C., Heikura, T., Vajanto, I., Greaves, D. R., Channons, K., & Ylä-Herttuala, S. (2005). Effects of vaccinia virus anti-inflammatory protein 35K and TIMP-1 gene transfers on vein graft stenosis in rabbits. In Vivo (Athens, Greece), 19(3), 515–521.

MLA Style

Puhakka, H. L., et al. “Effects of Vaccinia Virus Anti-Inflammatory Protein 35K and TIMP-1 Gene Transfers on Vein Graft Stenosis in Rabbits.” In Vivo (Athens, Greece), vol. 19, no. 3, 2005, pp. 515–21.

Chicago Style

Puhakka, HL, P Turunen, M Gruchala, C Bursill, T Heikura, I Vajanto, DR Greaves, K Channons, and S Ylä-Herttuala. 2005. “Effects of Vaccinia Virus Anti-Inflammatory Protein 35K and TIMP-1 Gene Transfers on Vein Graft Stenosis in Rabbits.” In Vivo (Athens, Greece) 19 (3): 515–21.
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