A putative functional polymorphism in the IGF-I gene: association studies with type 2 diabetes, adult height, glucose tolerance, and fetal growth in U.K. populations.

Journal article

IGF-I has a critical role in growth and metabolism. A microsatellite polymorphism 1 kb upstream to the IGF-I gene has recently been associated with several adult phenotypes. In a large Dutch cohort, the absence of the commonest allele (Z) was associated with reduced serum IGF-I levels, reduced height, and an increased risk of type 2 diabetes and myocardial infarction. This result has not been replicated, and the role of this polymorphism in these traits in U.K. subjects is not known. We sough...

Expand abstract

Authors: Frayling, T; Hattersley, A; McCarthy, A; Holly, J; Mitchell, S

• Journal: Diabetes
• Volume: 51
• Issue: 7
• Pages: 2313-2316
• Publication date: 2002-07-01
• DOI: 10.2337/diabetes.51.7.2313
• EISSN: 1939-327X
• ISSN: 0012-1797
• Language: English
• Keywords: Insulin-Like Growth Factor I; Humans; Adult; Polymorphism, Genetic; Diabetes Mellitus, Type 2; Embryonic and Fetal Development; Body Height; Great Britain; Blood Glucose