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Association between microchimerism and multiple sclerosis in Canadian twins.

Abstract:

Microchimerism, the persistence of foreign cells thought to derive from previous pregnancies, has been associated with autoimmune diseases. A maternal parent-of-origin effect in MS remains unexplained. We tested for microchimerism in monozygotic and dizygotic twin-pairs with MS. Microchimerism was associated with MS in affected females from monozygotic concordant pairs when compared to both affected (p=0.020) and unaffected (p=0.025) females in monozygotic discordant pairs. Microchimerism was...

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Publication status:
Published

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Authors


Willer, CJ More by this author
Herrera, BM More by this author
Morrison, KM More by this author
Sadovnick, AD More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience, WTC Human Genetics
Journal:
Journal of neuroimmunology
Volume:
179
Issue:
1-2
Pages:
145-151
Publication date:
2006-10-05
DOI:
EISSN:
1872-8421
ISSN:
0165-5728
URN:
uuid:3bfda8a0-d4d3-4792-9b30-e4d295183db8
Source identifiers:
33545
Local pid:
pubs:33545

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