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Structure of the periplasmic component of a bacterial drug efflux pump.

Abstract:

Multidrug resistance among Gram-negative bacteria is conferred by three-component membrane pumps that expel diverse antibiotics from the cell. These efflux pumps consist of an inner membrane transporter such as the AcrB proton antiporter, an outer membrane exit duct of the TolC family, and a periplasmic protein known as the adaptor. We present the x-ray structure of the MexA adaptor from the human pathogen Pseudomonas aeruginosa. The elongated molecule contains three linearly arranged subdoma...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0400375101

Authors


Higgins, MK More by this author
Koronakis, E More by this author
Koronakis, V More by this author
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
101
Issue:
27
Pages:
9994-9999
Publication date:
2004-07-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:3bfad7e7-9ca4-47ae-ba58-a4b03bdc524c
Source identifiers:
196860
Local pid:
pubs:196860

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