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Journal article

Diverse levels of sequence selectivity and catalytic efficiency of protein-tyrosine phosphatases.

Abstract:

The sequence selectivity of 14 classical protein-tyrosine phosphatases (PTPs) (PTPRA, PTPRB, PTPRC, PTPRD, PTPRO, PTP1B, SHP-1, SHP-2, HePTP, PTP-PEST, TCPTP, PTPH1, PTPD1, and PTPD2) was systematically profiled by screening their catalytic domains against combinatorial peptide libraries. All of the PTPs exhibit similar preference for pY peptides rich in acidic amino acids and disfavor positively charged sequences but differ vastly in their degrees of preference/disfavor. Some PTPs (PTP-PEST,...

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Publication status:
Published

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Publisher copy:
10.1021/bi401223r

Authors


Selner, NG More by this author
Luechapanichkul, R More by this author
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Journal:
Biochemistry
Volume:
53
Issue:
2
Pages:
397-412
Publication date:
2014-01-05
DOI:
EISSN:
1520-4995
ISSN:
0006-2960
URN:
uuid:3be889f5-8aaa-45b1-8112-3f50cea58190
Source identifiers:
448195
Local pid:
pubs:448195

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