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[Glycosphingolipids Gb3 and iGb3. In vivo roles in hemolytic-uremic syndrome and iNKT cell function].

Abstract:

UNLABELLED: The glycosphingolipids globotrihexosylceramide (Gb3, CD77) and isoglobotrihexosylceramide (iGb3) are isomers differing only in one glycosidic bond and have been implicated in several processes of the innate and adaptive immune system. AIMS: 1) To verify the function of Gb3 in the pathogenesis of hemolytic-uremic syndrome as the cellular receptor responsible for cytotoxicity caused by verotoxin (VT) elaborated by Shigella and certain strains of E.coli. 2) To investigate in vivo the...

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Publisher copy:
10.1007/s00292-008-1040-0

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
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Journal:
Der Pathologe
Volume:
29 Suppl 2
Issue:
S2
Pages:
297-302
Publication date:
2008-11-01
DOI:
EISSN:
1432-1963
ISSN:
0172-8113
Source identifiers:
34397
Language:
German
Keywords:
Pubs id:
pubs:34397
UUID:
uuid:3be0d029-1835-4f82-b536-5c042bc06f18
Local pid:
pubs:34397
Deposit date:
2012-12-19

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