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[Glycosphingolipids Gb3 and iGb3. In vivo roles in hemolytic-uremic syndrome and iNKT cell function].

Abstract:

UNLABELLED: The glycosphingolipids globotrihexosylceramide (Gb3, CD77) and isoglobotrihexosylceramide (iGb3) are isomers differing only in one glycosidic bond and have been implicated in several processes of the innate and adaptive immune system. AIMS: 1) To verify the function of Gb3 in the pathogenesis of hemolytic-uremic syndrome as the cellular receptor responsible for cytotoxicity caused by verotoxin (VT) elaborated by Shigella and certain strains of E.coli. 2) To investigate in vivo the...

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Publisher copy:
10.1007/s00292-008-1040-0

Authors


Porubsky, S More by this author
Bonrouhi, M More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine, Biomedical Research Centre
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Journal:
Der Pathologe
Volume:
29 Suppl 2
Issue:
S2
Pages:
297-302
Publication date:
2008-11-05
DOI:
EISSN:
1432-1963
ISSN:
0172-8113
URN:
uuid:3be0d029-1835-4f82-b536-5c042bc06f18
Source identifiers:
34397
Local pid:
pubs:34397

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