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Intrahepatic arterial versus intravenous fluorouracil and folinic acid for colorectal cancer liver metastases: a multicentre randomised trial.

Abstract:

BACKGROUND: The liver is the most frequent site for metastases of colorectal cancer, which is the second largest contributor to cancer deaths in Europe. We did a randomised trial to compare an intrahepatic arterial (IHA) fluorouracil and folinic acid regimen with the standard intravenous de Gramont fluorouracil and folinic acid regimen for patients with adenocarcinoma of the colon or rectum, with metastases confined to the liver. METHODS: We randomly allocated 290 patients from 16 centres to...

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Authors


McArdle, CS More by this author
Ledermann, J More by this author
Sherlock, DJ More by this author
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Journal:
Lancet
Volume:
361
Issue:
9355
Pages:
368-373
Publication date:
2003-02-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:3bdfc83b-6f75-4e6b-8e7a-659e73374b64
Source identifiers:
246382
Local pid:
pubs:246382

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