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Journal article

Viral macrodomains: Unique mediators of viral replication and pathogenesis.

Abstract:

Viruses from the Coronaviridae, Togaviridae, and Hepeviridae families ​all contain genes that encode a conserved protein domain, called a macrodomain; however, the role of this domain during infection has remained enigmatic. The recent discovery that mammalian macrodomain proteins enzymatically remove ADP-ribose, a common post-translation modification, from proteins has led to an outburst of studies describing both the enzymatic activity and function of viral macrodomains. These new studies h...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1016/j.tim.2017.11.011

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Perlman, S More by this author
Publisher:
Elsevier Publisher's website
Journal:
Trends in Microbiology Journal website
Volume:
26
Issue:
76
Pages:
598-610
Publication date:
2017-12-18
Acceptance date:
2017-12-18
DOI:
EISSN:
1878-4380
ISSN:
0966-842X
Pubs id:
pubs:812812
URN:
uri:3bd52bd3-0791-4923-85de-47f8e17a9755
UUID:
uuid:3bd52bd3-0791-4923-85de-47f8e17a9755
Local pid:
pubs:812812

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