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Sporadic--but not variant--Creutzfeldt-Jakob disease is associated with polymorphisms upstream of PRNP exon 1.

Abstract:

Human prion diseases have inherited, sporadic, and acquired etiologies. The appearance of the novel acquired prion disease, variant Creutzfeldt-Jakob disease (vCJD), and the demonstration that it is caused by the same prion strain as that causing bovine spongiform encephalopathy, has led to fears of a major human epidemic. The etiology of classical (sporadic) CJD, which has a worldwide incidence, remains obscure. A common human prion-protein-gene (PRNP) polymorphism (encoding either methionin...

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Publication status:
Published

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Publisher copy:
10.1086/324710

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
Role:
Author
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Journal:
American journal of human genetics
Volume:
69
Issue:
6
Pages:
1225-1235
Publication date:
2001-12-05
DOI:
EISSN:
1537-6605
ISSN:
0002-9297
URN:
uuid:3bbdd3ef-7a49-4afb-8294-dbee3e3311ed
Source identifiers:
104993
Local pid:
pubs:104993

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