- Abstract:
-
Human prion diseases have inherited, sporadic, and acquired etiologies. The appearance of the novel acquired prion disease, variant Creutzfeldt-Jakob disease (vCJD), and the demonstration that it is caused by the same prion strain as that causing bovine spongiform encephalopathy, has led to fears of a major human epidemic. The etiology of classical (sporadic) CJD, which has a worldwide incidence, remains obscure. A common human prion-protein-gene (PRNP) polymorphism (encoding either methionin...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1086/324710
-
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- Journal:
- American journal of human genetics
- Volume:
- 69
- Issue:
- 6
- Pages:
- 1225-1235
- Publication date:
- 2001-12-05
- DOI:
- EISSN:
-
1537-6605
- ISSN:
-
0002-9297
- URN:
-
uuid:3bbdd3ef-7a49-4afb-8294-dbee3e3311ed
- Source identifiers:
-
104993
- Local pid:
- pubs:104993
- Language:
- English
- Keywords:
- Copyright date:
- 2001
Journal article
Sporadic--but not variant--Creutzfeldt-Jakob disease is associated with polymorphisms upstream of PRNP exon 1.
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