A critical function for CD200 in lung immune homeostasis and the severity of influenza infection.

Journal article

The lung must maintain a high threshold of immune 'ignorance' to innocuous antigens to avoid inflammatory disease that depends on the balance of positive inflammatory signals and repressor pathways. We demonstrate here that airway macrophages had higher expression of the negative regulator CD200 receptor (CD200R) than did their systemic counterparts. Lung macrophages were restrained by CD200 expressed on airway epithelium. Mice lacking CD200 had more macrophage activity and enhanced sensitivi...

Expand abstract

Authors: Snelgrove, R; Goulding, J; Didierlaurent, A; Lyonga, D; Vekaria, S

• Journal: Nature immunology
• Volume: 9
• Issue: 9
• Pages: 1074-1083
• Publication date: 2008-09-01
• DOI: 10.1038/ni.1637
• EISSN: 1529-2916
• ISSN: 1529-2908
• Language: English
• Keywords: Humans; Homeostasis; Antigens, CD; Lung; Cytokines; Influenza, Human; Myeloid Cells; Mice; Animals