Polynesian origins and affinities: globin gene variants in eastern Polynesia.

Journal article

Analysis of copy number variants of the duplicated alpha-, zeta-, and gamma-globin genes in eastern Polynesians revealed a high frequency of both triplicated-zeta-gene chromosomes and a specific alpha thalassemia deletion. This deletion and a novel restriction-enzyme-site polymorphism associated with a zeta zeta zeta chromosome are found only in Melanesians and Polynesians. Analysis of alpha-globin restriction-enzyme haplotypes indicated further similarities to Melanesians but suggested an ad...

Expand abstract

Authors: Hill, A; Gentile, B; Bonnardot, J; Roux, J; Weatherall, D

• Publication status: Published
• Journal: American journal of human genetics
• Volume: 40
• Issue: 5
• Pages: 453-463
• Publication date: 1987-05-01
• EISSN: 1537-6605
• ISSN: 0002-9297
• Language: English
• Keywords: Genetic Variation; Genetic Markers; Humans; Alleles; Globins; Polynesia; Gene Frequency; Genetics, Population; Polymorphism, Restriction Fragment Length