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RASSF Signalling and DNA Damage: Monitoring the Integrity of the Genome?

Abstract:

The RASSF family of proteins has been extensively studied in terms of their genetics, structure and function. One of the functions that has been increasingly studied is the role of the RASSF proteins in the DNA damage response. Surprisingly, this research, which encompasses both the classical and N-terminal RASSF proteins, has revealed an involvement of the RASSFs in oncogenic pathways as well as the more familiar tumour suppressor pathways usually associated with the RASSF family members. Th...

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Publisher copy:
10.1155/2012/141732

Authors


Scrace, SF More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Journal:
Molecular biology international
Volume:
2012
Pages:
141732
Publication date:
2012
DOI:
EISSN:
2090-2190
ISSN:
2090-2182
URN:
uuid:3baf5a57-f208-4460-8eac-1893fa5d1df8
Source identifiers:
332810
Local pid:
pubs:332810
Language:
English

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