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Journal article

Evolutionary history of the Clostridium difficile pathogenicity locus.

Abstract:

The symptoms of Clostridium difficile infection are caused by toxins expressed from its 19 kb pathogenicity locus (PaLoc). Stable integration of the PaLoc is suggested by its single chromosomal location and the clade specificity of its different genetic variants. However, the PaLoc is variably present, even among closely related strains, and thus resembles a mobile genetic element. Our aim was to explain these apparently conflicting observations by reconstructing the evolutionary history of t...

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Publication status:
Published

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Publisher copy:
10.1093/gbe/evt204

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Journal:
Genome biology and evolution
Volume:
6
Issue:
1
Pages:
36-52
Publication date:
2014-01-01
DOI:
EISSN:
1759-6653
ISSN:
1759-6653
Source identifiers:
444162
Language:
English
Keywords:
Pubs id:
pubs:444162
UUID:
uuid:3ba99eae-2819-48b7-8979-59f5dfddb614
Local pid:
pubs:444162
Deposit date:
2014-02-08

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