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Evolutionary history of the Clostridium difficile pathogenicity locus.

Abstract:

The symptoms of Clostridium difficile infection are caused by toxins expressed from its 19 kb pathogenicity locus (PaLoc). Stable integration of the PaLoc is suggested by its single chromosomal location and the clade specificity of its different genetic variants. However, the PaLoc is variably present, even among closely related strains, and thus resembles a mobile genetic element. Our aim was to explain these apparently conflicting observations by reconstructing the evolutionary history of t...

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Publication status:
Published

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Publisher copy:
10.1093/gbe/evt204

Authors


Dingle, KE More by this author
Elliott, B More by this author
Robinson, E More by this author
Griffiths, D More by this author
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Journal:
Genome biology and evolution
Volume:
6
Issue:
1
Pages:
36-52
Publication date:
2014-01-05
DOI:
EISSN:
1759-6653
ISSN:
1759-6653
URN:
uuid:3ba99eae-2819-48b7-8979-59f5dfddb614
Source identifiers:
444162
Local pid:
pubs:444162

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