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Neutralization mechanisms of two highly potent antibodies against human enterovirus 71

Abstract:

Despite significant advances in health care, outbreaks of infections by enteroviruses (EVs) continue to plague the Asia-Pacific region every year. Enterovirus 71 (EV71) causes hand-foot-and-mouth disease (HFMD), for which there are currently no therapeutics. Here, we report two new antibodies, A9 and D6, that potently neutralize EV71. A9 exhibited a 50% neutralizing concentration (neut50) value of 0.1 nM against EV71, which was 10-fold lower than that observed for D6. Investigation into the m...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1128/mBio.1013.18

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Grant:
973 project (grant 2014CB542800)
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Grant:
Strategic Priority Research Program (grant XDB08020200)
Publisher:
American Society for Microbiology Publisher's website
Journal:
mBio Journal website
Volume:
9
Issue:
4
Pages:
e01013-18
Publication date:
2018-07-03
Acceptance date:
2018-06-12
DOI:
EISSN:
2150-7511
Pubs id:
pubs:921752
URN:
uri:3ba789fb-c447-4a40-98f6-81705ec9a97d
UUID:
uuid:3ba789fb-c447-4a40-98f6-81705ec9a97d
Local pid:
pubs:921752

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