Journal article
Neutralization mechanisms of two highly potent antibodies against human enterovirus 71
- Abstract:
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Despite significant advances in health care, outbreaks of infections by enteroviruses (EVs) continue to plague the Asia-Pacific region every year. Enterovirus 71 (EV71) causes hand-foot-and-mouth disease (HFMD), for which there are currently no therapeutics. Here, we report two new antibodies, A9 and D6, that potently neutralize EV71. A9 exhibited a 50% neutralizing concentration (neut50) value of 0.1 nM against EV71, which was 10-fold lower than that observed for D6. Investigation into the m...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 3.3MB, Terms of use)
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- Publisher copy:
- 10.1128/mBio.1013.18
Authors
Funding
+ Chinese Academy of Sciences
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Grant:
Strategic
Priority Research Program (grant XDB08020200
Bibliographic Details
- Publisher:
- American Society for Microbiology
- Journal:
- mBio More from this journal
- Volume:
- 9
- Issue:
- 4
- Pages:
- e01013-18
- Publication date:
- 2018-07-03
- Acceptance date:
- 2018-06-12
- DOI:
- EISSN:
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2150-7511
Item Description
- Keywords:
- Pubs id:
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pubs:921752
- UUID:
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uuid:3ba789fb-c447-4a40-98f6-81705ec9a97d
- Local pid:
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pubs:921752
- Source identifiers:
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921752
- Deposit date:
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2018-12-06
Terms of use
- Copyright holder:
- Zhu et al
- Copyright date:
- 2018
- Notes:
-
Copyright © 2018 Zhu et al.
This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
- Licence:
- CC Attribution (CC BY)
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