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Expression of the candidate circadian photopigment melanopsin (Opn4) in the mouse retinal pigment epithelium.

Abstract:

A number of responses to light, including circadian entrainment and pupillary constriction, are preserved in mammals that lack rod and cone photoreceptors. Recent studies have demonstrated that a subset of retinal ganglion cells (RGCs) are intrinsically photosensitive, and that these RGCs project to regions of the brain associated with the regulation of the circadian clock and pupil constriction. The photopigment gene(s) that mediate these effects of irradiance remain unidentified, although m...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Bovee-Geurts, PH More by this author
Jeffery, G More by this author
DeGrip, WJ More by this author
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Journal:
Brain research. Molecular brain research
Volume:
123
Issue:
1-2
Pages:
132-135
Publication date:
2004-04-05
DOI:
ISSN:
0169-328X
URN:
uuid:3ba06a20-7f36-4f64-8582-32888aaa218b
Source identifiers:
101417
Local pid:
pubs:101417

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