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Investigation of osteoclastogenic signalling of the RANKL substitute LIGHT

Abstract:

LIGHT (TNFSF14) is a member of the TNF superfamily and is known to substitute for RANKL to induce osteoclast differentiation. LIGHT binds HVEM and LTβR, but it is not known whether these receptors play a role in osteoclast formation or whether LIGHT acts via RANKL signalling pathways. We found that both RANKL and LIGHT strongly induced phosphorylation of Akt and NFκB but not JNK in mouse osteoclast precursor cells. The addition of an Akt inhibitor showed decreased osteoclast differentiation a...

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Publisher copy:
10.1016/j.yexmp.2013.01.003

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Journal:
Experimental and Molecular Pathology
Volume:
94
Issue:
2
Pages:
80-385
Publication date:
2013-04-05
DOI:
EISSN:
1096-0945
ISSN:
0014-4800
URN:
uuid:3b9f7897-93b6-46b2-810b-003298bad587
Source identifiers:
389204
Local pid:
pubs:389204
Language:
English
Keywords:

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