- Abstract:
-
LIGHT (TNFSF14) is a member of the TNF superfamily and is known to substitute for RANKL to induce osteoclast differentiation. LIGHT binds HVEM and LTβR, but it is not known whether these receptors play a role in osteoclast formation or whether LIGHT acts via RANKL signalling pathways. We found that both RANKL and LIGHT strongly induced phosphorylation of Akt and NFκB but not JNK in mouse osteoclast precursor cells. The addition of an Akt inhibitor showed decreased osteoclast differentiation a...
Expand abstract - Publisher copy:
- 10.1016/j.yexmp.2013.01.003
-
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- Journal:
- Experimental and Molecular Pathology
- Volume:
- 94
- Issue:
- 2
- Pages:
- 80-385
- Publication date:
- 2013-04-05
- DOI:
- EISSN:
-
1096-0945
- ISSN:
-
0014-4800
- URN:
-
uuid:3b9f7897-93b6-46b2-810b-003298bad587
- Source identifiers:
-
389204
- Local pid:
- pubs:389204
- Copyright date:
- 2013
Journal article
Investigation of osteoclastogenic signalling of the RANKL substitute LIGHT
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