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Layered reward signalling through octopamine and dopamine in Drosophila

Abstract:

Dopamine is synonymous with reward and motivation in mammals. However, only recently has dopamine been linked to motivated behaviour and rewarding reinforcement in fruitflies. Instead, octopamine has historically been considered to be the signal for reward in insects. Here we show, using temporal control of neural function in Drosophila, that only short-term appetitive memory is reinforced by octopamine. Moreover, octopamine-dependent memory formation requires signalling through dopamine neur...

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Publisher copy:
10.1038/nature11614

Authors


Huetteroth, W More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Perisse, E More by this author
Krashes, MJ More by this author
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Journal:
Nature
Volume:
492
Issue:
7429
Pages:
433-437
Publication date:
2012-12-20
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:3b9dbfd2-faa9-4776-b562-e82d7923ceaf
Source identifiers:
371615
Local pid:
pubs:371615
Language:
English

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