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Morbidity and mortality in rheumatoid arthritis patients with prolonged and profound therapy-induced lymphopenia.

Abstract:

OBJECTIVE: Therapies that deplete lymphocytes often improve symptoms in patients with otherwise refractory autoimmune disease but may result in long-term lymphopenia, the consequences of which are uncertain. To assess the impact of prolonged lymphopenia on morbidity and mortality, we studied patients who had previously received lymphocytotoxic monoclonal antibody (mAb) therapy for rheumatoid arthritis (RA). METHODS: Fifty-three patients who received the lymphocytotoxic mAb CAMPATH-1H between...

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Publication status:
Published

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Authors


Isaacs, JD More by this author
Symmons, D More by this author
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Journal:
Arthritis and rheumatism
Volume:
44
Issue:
9
Pages:
1998-2008
Publication date:
2001-09-05
DOI:
EISSN:
1529-0131
ISSN:
0004-3591
URN:
uuid:3b9a18e8-1d9a-43dc-b5c9-19a24d4f672c
Source identifiers:
7150
Local pid:
pubs:7150

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