Early changes in white matter pathways of the sensorimotor cortex in premanifest Huntington's disease.

Journal article

OBJECTIVES: To investigate the function-structure relationship of white matter within different stages of Huntington's disease (HD) using diffusion tensor imaging (DTI). EXPERIMENTAL DESIGN: From the TRACK-HD study, an early stage HD group and a premanifest gene carrier group (PMGC) were age-matched to two healthy control groups; all underwent 3-T MRI scanning of the brain. Region of interest (ROI) segmentation of the corpus callosum, caudate nucleus, thalamus, prefrontal cortex, and sensori...

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Authors: Dumas, E; van den Bogaard, S; Ruber, M; Reilman, R; Stout, J

• Publication status: Published
• Journal: Human brain mapping
• Volume: 33
• Issue: 1
• Pages: 203-212
• Publication date: 2012-01-01
• DOI: 10.1002/hbm.21205
• EISSN: 1097-0193
• ISSN: 1065-9471
• Language: English
• Keywords: Adult; Diffusion Tensor Imaging; Huntington Disease; Disease Progression; Neuropsychological Tests; Brain Mapping; Female; Middle Aged; Brain; Humans; Motor Cortex; Nerve Fibers, Myelinated; Male