Many randomized trials have evaluated alpha-interferon as myeloma therapy, some suggesting a benefit and others not. Most were too small to give reliable answers, so a systematic overview has been performed to provide a more reliable estimate of the effect of interferon. The main end-points were response rates (induction trials), progression-free survival (PFS) and overall survival (OS). Individual patient data were supplied for 24 trials involving 4012 patients, 12 induction trials (2469 pat...Expand abstract
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Interferon as therapy for multiple myeloma: an individual patient data overview of 24 randomized trials and 4012 patients.
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