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Exploitation of cavitation-enhanced heating for release of doxorubicin from thermosensitve liposomes by therapeutic ultrasound.

Abstract:

The systemic toxicity of current chemotherapeutic treatments motivates the investigation of targeted delivery techniques to restrict the action of drugs to the tumor region. ThermoDox(©) copyright (Celsion Corporation) consists of doxorubicin, a common anticancer agent, encapsulated within thermally sensitive liposomes designed to release their contents above 39 °C. Activation of such an agent with the use of HIFU, which can generate localized heating non-invasively, potentially combines the ...

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Publisher copy:
10.1121/1.3508631

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Role:
Author
Volume:
128
Issue:
4
Pages:
2418
Host title:
J Acoust Soc Am
Publication date:
2010-10-01
Event location:
United States
DOI:
ISSN:
1520-8524
Source identifiers:
90811
Pubs id:
pubs:90811
UUID:
uuid:3b843f1a-7f35-43b1-830d-24e5f1756e0e
Local pid:
pubs:90811
Deposit date:
2012-12-20

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