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Exploitation of cavitation-enhanced heating for release of doxorubicin from thermosensitve liposomes by therapeutic ultrasound.

Abstract:

The systemic toxicity of current chemotherapeutic treatments motivates the investigation of targeted delivery techniques to restrict the action of drugs to the tumor region. ThermoDox(©) copyright (Celsion Corporation) consists of doxorubicin, a common anticancer agent, encapsulated within thermally sensitive liposomes designed to release their contents above 39 °C. Activation of such an agent with the use of HIFU, which can generate localized heating non-invasively, potentially combines the ...

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Publisher copy:
10.1121/1.3508631

Authors


Mylonopoulou, E More by this author
Bazan-Peregrino, M More by this author
Arvanitis, CD More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Engineering Science
Volume:
128
Issue:
4
Pages:
2418
Publication date:
2010-10-05
DOI:
ISSN:
1520-8524
URN:
uuid:3b843f1a-7f35-43b1-830d-24e5f1756e0e
Source identifiers:
90811
Local pid:
pubs:90811

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