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Journal article

Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation.

Abstract:

Mutations in the human methyl-CpG-binding protein gene MECP2 cause the neurological disorder Rett syndrome and some cases of X-linked mental retardation (XLMR). We report that MeCP2 interacts with ATRX, a SWI2/SNF2 DNA helicase/ATPase that is mutated in ATRX syndrome (alpha-thalassemia/mental retardation, X-linked). MeCP2 can recruit the helicase domain of ATRX to heterochromatic foci in living mouse cells in a DNA methylation-dependent manner. Also, ATRX localization is disrupted in neurons ...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0608056104

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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
104
Issue:
8
Pages:
2709-2714
Publication date:
2007-02-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:3b7f5601-c52c-4441-a84f-d4d24c61515d
Source identifiers:
90266
Local pid:
pubs:90266

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