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Journal article

IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis

Abstract:

The HIV capsid is semipermeable and covered in electropositive pores that are essential for viral DNA synthesis and infection. Here, we show that these pores bind the abundant cellular polyanion IP6, transforming viral stability from minutes to hours and allowing newly synthesised DNA to accumulate inside the capsid. An arginine ring within the pore coordinates IP6, which strengthens capsid hexamers by almost 10°C. Single molecule measurements demonstrate that this renders native HIV capsids ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.7554/eLife.35335

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Role:
Author
ORCID:
0000-0002-4408-0407
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Role:
Author
ORCID:
0000-0002-6426-4510
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Publisher:
eLife Sciences Publisher's website
Journal:
eLife Journal website
Volume:
7
Pages:
e35335
Publication date:
2018-05-31
Acceptance date:
2018-05-29
DOI:
EISSN:
2050-084X
Pmid:
29848441
Source identifiers:
856642
Language:
English
Keywords:
Pubs id:
pubs:856642
UUID:
uuid:3b79a6e7-78b6-4d8c-9207-daa3e75af593
Local pid:
pubs:856642
Deposit date:
2018-09-11

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