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Journal article

Therapeutic antibodies elicited by immunization against TNF-alpha.

Abstract:

Tumor necrosis factor-alpha (TNF-alpha) is critically involved in the pathogenesis of several chronic inflammatory diseases. Monoclonal antibodies against TNF-alpha are currently used for the treatment of rheumatoid arthritis and Crohn's disease. This report describes a simple and effective method for active immunization against self TNF-alpha. This vaccination approach leads to a T-cell-dependent polyclonal and sustainable anti-TNF-alpha autoantibody response that declines upon discontinuati...

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Publication status:
Published

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Publisher copy:
10.1038/10878

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Journal:
Nature biotechnology
Volume:
17
Issue:
7
Pages:
666-669
Publication date:
1999-07-01
DOI:
EISSN:
1546-1696
ISSN:
1087-0156
Source identifiers:
481925
Language:
English
Keywords:
Pubs id:
pubs:481925
UUID:
uuid:3b775f49-5a17-425d-8e4d-caf5a8f53ccb
Local pid:
pubs:481925
Deposit date:
2014-08-29

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