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Fibroblast growth factor controls the timing of Scl, Lmo2, and Runx1 expression during embryonic blood development.

Abstract:

To program pluripotent cells into blood, a knowledge of the locations of precursors during their journey through the embryo and the signals they experience would be informative. The anterior (a) and posterior (p) ventral blood islands (VBIs) in Xenopus are derived from opposite sides of the pregastrula embryo. The aVBI goes through a "hemangioblast" state, characterized by coexpression of blood and endothelial genes at neurula stages, whereas the pVBI expresses these genes in a nonoverlapping...

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Publication status:
Published

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Authors


Walmsley, M More by this author
Cleaver, D More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine, BHF Centre of Research Excellence
Journal:
Blood
Volume:
111
Issue:
3
Pages:
1157-1166
Publication date:
2008-02-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:3b6bdbd5-571b-4160-8c6a-e9b55f254999
Source identifiers:
106550
Local pid:
pubs:106550

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