Rheological analysis of the adhesive interactions of red blood cells parasitized by Plasmodium falciparum.

Journal article

Adhesion of parasitized red blood cells (RBCs) to vascular endothelium is thought to be a key factor in the pathology of falciparum malaria. However, quantitative analyses of the intercellular forces and of the effects of flow on adhesion have been lacking. We have characterized cytoadhesion of RBCs parasitized by the strains ITO4 (which can bind to receptors ICAM-1 or CD36) and FCR3A2 (which can bind to CD36 only) using micropipette manipulation and flow chamber techniques. Target cells were...

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Authors: Nash, G; Cooke, B; Marsh, K; Berendt, A; Newbold, C

• Publication status: Published
• Journal: Blood
• Volume: 79
• Issue: 3
• Pages: 798-807
• Publication date: 1992-02-01
• EISSN: 1528-0020
• ISSN: 0006-4971
• Language: English
• Keywords: Animals; Glutaral; Endothelium, Vascular; Plasmodium falciparum; Malaria, Falciparum; Cell Adhesion; Rheology; Erythrocytes; Humans; Temperature