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Evidence of macrophage receptors capable of direct recognition of xenogeneic epitopes without opsonization.

Abstract:

BACKGROUND: We have previously demonstrated that porcine livers perfused with human blood remove most of the erythrocytes from three units of human blood over the course of a 72-h extracorporeal perfusion. Red blood cell loss did not appear to involve classical complement pathway-mediated hemolysis, but instead resulted from porcine Kupffer cell phagocytosis. METHODS: We developed a method incorporating collagenase digestion and metrizamide separation to isolate and maintain porcine Kupffer ...

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Journal:
Xenotransplantation
Volume:
12
Issue:
1
Pages:
13-19
Publication date:
2005-01-05
DOI:
EISSN:
1399-3089
ISSN:
0908-665X
URN:
uuid:3b5d1952-4e13-4544-bae7-edce0f9f0315
Source identifiers:
147684
Local pid:
pubs:147684

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