Platelet 5-HT receptor binding during depressive illness and tricyclic antidepressant treatment.

Journal article

5-Hydroxytryptamine (5-HT) receptor binding was determined in intact human platelets using 125I-iodolysergic acid diethylamide (125I-iodoLSD). The assay revealed that platelets possess a single population of specific binding sites for 125I-iodoLSD which have a high affinity for the 5-HT2 receptor antagonists, ketanserin and spiperone. There was no difference in platelet 125I-iodoLSD receptor binding between depressed patients and controls. However, treatment with tricyclic antidepressants inc...

Expand abstract

Authors: Cowen, P; Charig, E; Fraser, S; Elliott, J

• Publication status: Published
• Journal: Journal of affective disorders
• Volume: 13
• Issue: 1
• Pages: 45-50
• Publication date: 1987-01-01
• DOI: 10.1016/0165-0327(87)90072-3
• EISSN: 1573-2517
• ISSN: 0165-0327
• Language: English
• Keywords: Iodine Radioisotopes; Binding Sites; Female; Receptors, Serotonin; Adult; Middle Aged; Male; Antidepressive Agents, Tricyclic; Humans; Blood Platelets; Depressive Disorder