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A CD45 polymorphism associated with abnormal splicing is absent in African populations.

Abstract:

The CD45 antigen is essential for normal antigen receptor-mediated signalling in lymphocytes, and different patterns of splicing of CD45 are associated with distinct functions in lymphocytes. Abnormal CD45 splicing has been recognized in humans, caused by a C77G transversion in the gene encoding CD45 (PTPRC). Recently the C77G polymorphism has been associated with multiple sclerosis and increased susceptibility to HIV-1 infection. These studies suggest that the regulation of CD45 splicing may...

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Publisher copy:
10.1007/s00251-001-0410-z

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Journal:
Immunogenetics
Volume:
53
Issue:
10-11
Pages:
980-983
Publication date:
2002-02-05
DOI:
EISSN:
1432-1211
ISSN:
0093-7711
URN:
uuid:3b5a3a7d-0d6a-435c-aeef-31025c441fa3
Source identifiers:
32060
Local pid:
pubs:32060

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