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Journal article

RNA packaging motor: From structure to quantum mechanical modelling and sequential-stochastic mechanism

Abstract:

The bacteriophages of the Cystoviridae family package their single stranded RNA genomic precursors into empty capsid (procapsids) using a hexameric packaging ATPase motor (P4). This molecular motor shares sequence and structural similarity with RecA-like hexameric helicases. A concerted structural, mutational and kinetic analysis helped to define the mechanical reaction coordinate, i.e. the conformational changes associated with RNA translocation. The results also allowed us to propose a poss...

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Publication status:
Published

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Publisher copy:
10.1080/17486700802168502

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
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Journal:
COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
Volume:
9
Issue:
3-4
Pages:
351-369
Publication date:
2008-01-01
DOI:
EISSN:
1748-6718
ISSN:
1748-670X
Source identifiers:
7054
Language:
English
Keywords:
Pubs id:
pubs:7054
UUID:
uuid:3b429d6e-df44-4c87-8faa-6ac5e40e5665
Local pid:
pubs:7054
Deposit date:
2012-12-19

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