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Thesis

Towards the development of vascularized constructs for bone repair

Abstract:

The development of a vasculature within a tissue-engineered construct is one of the largest hurdles to successful bone regeneration. This thesis investigates methods to increase vasculature of such transplanted constructs, based on in vivo transplant studies and in vitro analysis of cell behaviors. A syngeneic mouse model in immunocompetent mice was developed and analyzed for both osteogenesis and hematopoiesis. This study demonstrates that syngeneic bone marrow stroma...

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Institution:
University of Oxford
Oxford college:
Wolfson College
Department:
Medical Sciences Division - NDORMS (Nuffield Department of Orthopaedics,Rheumatology and Musculoskeletal Sciences)
Role:
Author

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Role:
Supervisor
Role:
Supervisor
Role:
Supervisor
Role:
Supervisor
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Funding agency for:
Nolanne Arlette Chang-Wai-Ling
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Funding agency for:
Nolanne Arlette Chang-Wai-Ling
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:3b40e823-007b-47a5-88a1-e63ae06f2d4d
Local pid:
ora:8136

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