OBJECTIVE: Endothelial dysfunction in diabetes is characterized by decreased nitric oxide (NO) bioactivity and increased superoxide (SO) production. Reduced levels of tetrahydrobiopterin (BH4), an essential cofactor of endothelial NO synthase (eNOS), appear to be associated with eNOS enzymatic uncoupling. We sought to investigate whether augmented BH4 biosynthesis in hyperglycemic human aortic endothelial cells (HAEC) by adenovirus-mediated gene transfer of GTP cyclohydrolase I (GTPCH, the r...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date:
Augmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cells.
If you are the owner of this record, you can report an update to it here: Report update to this record