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Augmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cells.

Abstract:

OBJECTIVE: Endothelial dysfunction in diabetes is characterized by decreased nitric oxide (NO) bioactivity and increased superoxide (SO) production. Reduced levels of tetrahydrobiopterin (BH4), an essential cofactor of endothelial NO synthase (eNOS), appear to be associated with eNOS enzymatic uncoupling. We sought to investigate whether augmented BH4 biosynthesis in hyperglycemic human aortic endothelial cells (HAEC) by adenovirus-mediated gene transfer of GTP cyclohydrolase I (GTPCH, the r...

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Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
Journal:
Cardiovascular research
Volume:
65
Issue:
4
Pages:
823-831
Publication date:
2005-03-05
DOI:
EISSN:
1755-3245
ISSN:
0008-6363
URN:
uuid:3b3dafef-15e5-44d5-aa43-1316b8b0e2f3
Source identifiers:
105269
Local pid:
pubs:105269

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