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Elevation of intact and proteolytic fragments of acute phase proteins constitutes the earliest systemic antiviral response in HIV-1 infection.

Abstract:

The earliest immune responses activated in acute human immunodeficiency virus type 1 infection (AHI) exert a critical influence on subsequent virus spread or containment. During this time frame, components of the innate immune system such as macrophages and DCs, NK cells, beta-defensins, complement and other anti-microbial factors, which have all been implicated in modulating HIV infection, may play particularly important roles. A proteomics-based screen was performed on a cohort from whom sa...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.ppat.1000893

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Institution:
University of Oxford
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Institution:
University of Oxford
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Institution:
University of Oxford
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Institution:
University of Oxford
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Author
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Funding agency for:
McMichael, A
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Funding agency for:
Borrow, P
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Pathog Journal website
Volume:
6
Issue:
5
Article number:
e1000893
Publication date:
2010-05-01
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
Source identifiers:
54759

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