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Use of Minimal Residual Disease Assessment to Redefine Induction Failure in Pediatric Acute Lymphoblastic Leukemia.

Abstract:

Purpose
Our aim was to determine the role of end-of-induction (EOI) minimal residual disease (MRD) assessment in the identification and stratification of induction failure in patients with pediatric acute lymphoblastic leukemia (ALL) and to identify genetic abnormalities that drive disease in these patients.

Patients and Methods
Analysis included 3,113 patients who were treated in the Medical Research Council UKALL2003 multicenter randomized trial (NCT0...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1200/JCO.2016.69.6278

Authors


O'Connor, D More by this author
Moorman, AV More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Nuffield Department of Population Health, Clinical Trial Service Unit
Hancock, J More by this author
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Publisher:
American Society of Clinical Oncology Publisher's website
Journal:
Journal of Clinical Oncology Journal website
Volume:
35
Issue:
6
Pages:
660-667
Publication date:
2017-01-03
Acceptance date:
2016-10-25
DOI:
EISSN:
1527-7755
ISSN:
0732-183X
Pubs id:
pubs:671005
URN:
uri:3b3b91b3-e851-4ddb-badf-8b8379bb6a5e
UUID:
uuid:3b3b91b3-e851-4ddb-badf-8b8379bb6a5e
Local pid:
pubs:671005
Paper number:
6
Language:
English
Keywords:

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