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The new (dis)order in RNA regulation

Abstract:

RNA-binding proteins play a key role in the regulation of all aspects of RNA metabolism, from the synthesis of RNA to its decay. Protein-RNA interactions have been thought to be mostly mediated by canonical RNA-binding domains that form stable secondary and tertiary structures. However, a number of pioneering studies over the past decades, together with recent proteome-wide data, have challenged this view, revealing surprising roles for intrinsically disordered protein regions in RNA binding....

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s12964-016-0132-3

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
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Funding agency for:
Davis, I
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Funding agency for:
Castello, A
Publisher:
BioMed Central Publisher's website
Journal:
Cell Communication and Signaling Journal website
Volume:
14
Pages:
Article: 9
Publication date:
2016-04-05
DOI:
EISSN:
1478-811X
ISSN:
1478-811X
URN:
uuid:3b37affe-f24b-4fb6-9247-66e98c1b87ed
Source identifiers:
611231
Local pid:
pubs:611231

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