Evidence for abnormalities of cortical development in adolescent-onset schizophrenia.

Journal article

Voxel-Based Morphometry (VBM) identifies differences in grey matter brain structure in patients with schizophrenia relative to healthy controls, with particularly prominent differences found in patients with the more severe, adolescent-onset form of the disease. However, as VBM is sensitive to a combination of changes in grey matter thickness, intensity and folding, specific neuropathological interpretations are not possible. Here, we attempt to more precisely define cortical changes in 25 ad...

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Authors: Voets, N; Hough, MG; Douaud, G; Matthews, P; James, A

• Publication status: Published
• Journal: NeuroImage
• Volume: 43
• Issue: 4
• Pages: 665-675
• Publication date: 2008-12-01
• DOI: 10.1016/j.neuroimage.2008.08.013
• EISSN: 1095-9572
• ISSN: 1053-8119
• Language: English
• Keywords: Humans; Female; Magnetic Resonance Imaging; Male; Adolescent; Schizophrenia; Neurons; Evidence-Based Medicine; Image Interpretation, Computer-Assisted; Imaging, Three-Dimensional; Cerebral Cortex