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Minimum efficacy criteria for comparisons between treatments using individual patient meta-analysis of acute pain trials: examples of etoricoxib, paracetamol, ibuprofen, and ibuprofen/paracetamol combinations after third molar extraction.

Abstract:

We defined response in acute pain trials according to percentage of maximum possible efficacy. Minimum efficacy criteria (MEC) of 0%, or at least 15%, 30%, 50%, and 70% pain relief were used to examine stability over time using total pain relief and summed pain intensity difference (SPID), sex differences, and sensitivity. We used individual patient data from placebo-controlled third molar extraction trials: 4 with single-dose oral etoricoxib 120 mg, and 2 with paracetamol, ibuprofen, and ibu...

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Publication status:
Published

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Publisher copy:
10.1016/j.pain.2010.11.030

Authors


Straube, S More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
McQuay, HJ More by this author
Journal:
Pain
Volume:
152
Issue:
5
Pages:
982-989
Publication date:
2011-05-05
DOI:
EISSN:
1872-6623
ISSN:
0304-3959
URN:
uuid:3b2a24dc-a18d-4299-a0bd-738c911409cd
Source identifiers:
241216
Local pid:
pubs:241216

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