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Journal article

Tat-dependent occlusion of the HIV poly(A) site.

Abstract:

Retroviruses must ensure that poly(A) signals in the 3' LTR are highly active, while identical signals in the 5' LTR are inactive (occluded). In the case of HIV-1, both promoter proximity in the 5' LTR and U3 sequences in the 3' LTR may contribute to this regulation. We have discovered a novel regulatory mechanism for poly(A) site occlusion in HIV-1. When transcription initiation from the HIV promoter is activated by Tat, the HIV poly(A) site is specifically occluded, while other poly(A) site...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
EMBO journal
Volume:
12
Issue:
5
Pages:
2119-2128
Publication date:
1993-05-01
EISSN:
1460-2075
ISSN:
0261-4189
Source identifiers:
27055

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