Influence of the HLA-DRB1 locus on susceptibility and severity in rheumatoid arthritis.

Journal article

We examined HLA-DR genotype risk in 288 patients with rheumatoid arthritis who were carefully categorized for disease severity. Five hundred ethnically-matched bone-marrow donors were controls. A hierarchy of positive allelic associations was noted with DRB1*0401 (p < 10(-38), *0404,8 (p < 10(-43), *0405 (p < 10(-8), *10 (p < 10(-3) and *0101,2 (p < 10(-2), while DRB1*0403 was negatively associated (p = 0.02). The DRB1 genotype relative risks (and 95% CIs) for RA were: *0404,5,...

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Authors: Hall, F; Weeks, D; Camilleri, J; Williams, L; Amos, N

• Publication status: Published
• Journal: QJM : monthly journal of the Association of Physicians
• Volume: 89
• Issue: 11
• Pages: 821-829
• Publication date: 1996-11-01
• DOI: 10.1093/qjmed/89.11.821
• EISSN: 1460-2393
• ISSN: 1460-2725
• Language: English
• Keywords: Middle Aged; Prospective Studies; Chromosome Mapping; Polymorphism, Single-Stranded Conformational; HLA-DR1 Antigen; Humans; Genotype; Risk; Female; Arthritis, Rheumatoid; Male; Disease Susceptibility; Gene Frequency