Journal article icon

Journal article

Multicenter evaluation of neurofilaments in early symptomatic amyotrophic lateral sclerosis

Abstract:

Objective: To examine Nf concentrations according to symptom onset and clinical diagnostic certainty categories of ALS.

Methods: We measured Nf light chain (NfL) and phosphorylated Nf heavy chain (pNfH) CSF and NfL serum levels in ALS patients with first symptom onset ≤6 months (n=48), >6 months (n=128) from sampling, patients with other neurological diseases, differential diagnoses of a motor neuron disease (MND mimics) and other MND variants to...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neurosciences
Role:
Author
Expand authors...
More from this funder
Grant:
FTLDc O1GI1007A, KKMS, MND-Net 01GM1103A, PYRAMID01GM1304
More from this funder
Grant:
NADINE 246513, FAIRPARK II 633190
Publisher:
American Academy of Neurology Publisher's website
Journal:
Neurology Journal website
Volume:
90
Issue:
1
Pages:
e22-e30
Publication date:
2017-12-06
Acceptance date:
2017-09-21
DOI:
EISSN:
0028-3878
ISSN:
1526-632X
Pubs id:
pubs:728795
URN:
uri:3b20ed7a-ee19-44fe-9350-37332d522215
UUID:
uuid:3b20ed7a-ee19-44fe-9350-37332d522215
Local pid:
pubs:728795
Paper number:
1

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP