- Abstract:
-
Objective: To examine Nf concentrations according to symptom onset and clinical diagnostic certainty categories of ALS.
Methods: We measured Nf light chain (NfL) and phosphorylated Nf heavy chain (pNfH) CSF and NfL serum levels in ALS patients with first symptom onset ≤6 months (n=48), >6 months (n=128) from sampling, patients with other neurological diseases, differential diagnoses of a motor neuron disease (MND mimics) and other MND variants to...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted Manuscript
- Publisher copy:
- 10.1212/WNL.0000000000004761
-
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- Grant:
- SOPHIA (01ED1202A); BiomarkAPD (01ED1203F)
- Grant:
- FTLDc O1GI1007A, KKMS, MND-Net 01GM1103A, PYRAMID01GM1304
- Publisher:
- American Academy of Neurology Publisher's website
- Journal:
- Neurology Journal website
- Volume:
- 90
- Issue:
- 1
- Pages:
- e22-e30
- Publication date:
- 2017-12-06
- Acceptance date:
- 2017-09-21
- DOI:
- EISSN:
-
0028-3878
- ISSN:
-
1526-632X
- Pubs id:
-
pubs:728795
- URN:
-
uri:3b20ed7a-ee19-44fe-9350-37332d522215
- UUID:
-
uuid:3b20ed7a-ee19-44fe-9350-37332d522215
- Local pid:
- pubs:728795
- Paper number:
- 1
- Copyright holder:
- American Academy of Neurology
- Copyright date:
- 2017
- Notes:
-
Copyright © 2017 American Academy of Neurology.
Journal article
Multicenter evaluation of neurofilaments in early symptomatic amyotrophic lateral sclerosis
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+ EU Joint Programme – Neurodegenerative Disease Research
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+ German Federal Ministry of Education and Research
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