Remote ischemic preconditioning impairs ventricular function and increases infarct size after prolonged ischemia in the isolated neonatal rabbit heart.

Journal article

OBJECTIVES: Remote ischemic preconditioning (rIPC) reduces myocardial injury in adults and children undergoing cardiac surgery. We compared the effect of rIPC in adult and neonatal rabbits to investigate whether protection against ischemia-reperfusion injury can be achieved in the newborn heart by (1) in vivo rIPC and (2) dialysate from adult rabbits undergoing rIPC. METHODS: Isolated hearts from newborn and adult rabbits were randomized into 3 subgroups (control, in vivo rIPC, and dialysate ...

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Authors: Schmidt, MR; Støttrup, N; Michelsen, M; Contractor, H; Sørensen, K

• Publication status: Published
• Journal: Journal of thoracic and cardiovascular surgery
• Volume: 147
• Issue: 3
• Pages: 1049-1055
• Publication date: 2014-03-01
• DOI: 10.1016/j.jtcvs.2013.05.022
• EISSN: 1097-685X
• ISSN: 0022-5223
• Language: English
• Keywords: Time Factors; Animals, Newborn; Lower Extremity; Ventricular Function, Left; Age Factors; Glycolysis; Risk Factors; Ischemic Preconditioning; Myocardium; Myocardial Infarction; Animals; Rabbits; Ventricular Dysfunction, Left; Regional Blood Flow; Myocardial Reperfusion Injury; Perfusion