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Journal article

Vaccine route, dose and type of delivery vector determine patterns of primary CD8+ T cell responses.

Abstract:

The dynamics of primary CD8+ T cell responses following administration of modified virus Ankara (MVA)- and DNA-vectored vaccines was investigated in a mouse model. To overcome the low frequency of naive antigen-specific precursors and follow the early expansion events, naive CFSE-labelled T cell receptor-transgenic F5 lymphocytes were transferred into syngeneic non-transgenic recipients prior to vaccination. Using the i.d., i.v. and i.m. routes and increasing recombinant MVA (rMVA) vaccine do...

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Publication status:
Published

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Publisher copy:
10.1002/eji.200535184

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Role:
Author
Journal:
European journal of immunology
Volume:
35
Issue:
9
Pages:
2532-2540
Publication date:
2005-09-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:3b1a9c1d-cfbb-4ac7-8c2c-2133971f8fcd
Source identifiers:
33222
Local pid:
pubs:33222

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