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Identification of antigens specific to non-tuberculous mycobacteria: the Mce family of proteins as a target of T cell immune responses.

Abstract:

The lack of an effective TB vaccine hinders current efforts in combating the TB pandemic. One theory as to why BCG is less protective in tropical countries is that exposure to non-tuberculous mycobacteria (NTM) reduces BCG efficacy. There are currently several new TB vaccines in clinical trials, and NTM exposure may also be relevant in this context. NTM exposure cannot be accurately evaluated in the absence of specific antigens; those which are known to be present in NTM and absent from M. tu...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0026434

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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Jenner Institute
Role:
Author
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Institution:
University of Oxford
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Jenner Institute
Role:
Author
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Funding agency for:
Checkley, AM
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Funding agency for:
McShane, H
Medical Research Council More from this funder
Wellcome Trust More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
6
Issue:
10
Pages:
Article: e26434
Chapter number:
ARTN e26434
Publication date:
2011-01-05
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:3b0f6bf3-7ba4-4d15-87f8-7e2988f783e0
Source identifiers:
198767
Local pid:
pubs:198767

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