Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse.

Journal article

The T-box transcription factor eomesodermin (Eomes) has been implicated as an important component in germ layer induction and patterning in vertebrate embryos. In the mouse, Eomes is essential for development of the trophectoderm lineage and Eomes loss-of-function mutants arrest at implantation. Here, we have used a novel Eomes conditional allele to test Eomes functions in the embryo proper. Eomes-deficient embryos express both Fgf8 and its downstream target Snail at normal levels but surpris...

Expand abstract

Authors: Arnold, S; Hofmann, UK; Bikoff, E; Robertson, E

• Publication status: Published
• Journal: Development (Cambridge, England)
• Volume: 135
• Issue: 3
• Pages: 501-511
• Publication date: 2008-02-01
• DOI: 10.1242/dev.014357
• EISSN: 1477-9129
• ISSN: 0950-1991
• Language: English
• Keywords: Transforming Growth Factor beta; Down-Regulation; Body Patterning; Integrases; Embryo, Mammalian; Animals; T-Box Domain Proteins; Nodal Protein; Embryo Loss; Endoderm; Mice; Mutation; Models, Biological; Cadherins; Gene Expression Regulation, Developmental; Mesoderm; Cell Movement; Gene Deletion; Gastrulation; Epithelium; Alleles; Heterozygote; Germ Layers