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Journal article

Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain.

Abstract:

Epigenetic processes play a key role in the central nervous system and altered levels of 5-methylcytosine have been associated with a number of neurologic phenotypes, including Alzheimer's disease (AD). Recently, 3 additional cytosine modifications have been identified (5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine), which are thought to be intermediate steps in the demethylation of 5-methylcytosine to unmodified cytosine. Little is known about the frequency of these modif...

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Journal:
Neurobiology of aging
Volume:
35
Issue:
8
Pages:
1850-1854
Publication date:
2014-08-01
DOI:
EISSN:
1558-1497
ISSN:
0197-4580
Source identifiers:
460562
Language:
English
Keywords:
Pubs id:
pubs:460562
UUID:
uuid:3af9728b-a3e0-4693-b1e2-f29670ed2006
Local pid:
pubs:460562
Deposit date:
2014-06-16

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