A linkage study across the T cell receptor A and T cell receptor B loci in families with rheumatoid arthritis.

Journal article

OBJECTIVE: To examine whether the T cell receptor (TCR) A or TCRB loci exhibit linkage with disease in multiplex rheumatoid arthritis (RA) families. METHODS: A linkage study was performed in 184 RA families from the UK Arthritis and Rheumatism Council Repository, each containing at least 1 affected sibpair. The microsatellites D14S50, TCRA, and D14S64 spanning the TCRA locus and D7S509, Vbeta6.7, and D7S688 spanning the TCRB locus were used as DNA markers. The subjects were genotyped using a...

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Authors: Hall, F; Brown, M; Weeks, D; Walsh, S; Nicod, A

• Publication status: Published
• Journal: Arthritis and rheumatism
• Volume: 40
• Issue: 10
• Pages: 1798-1802
• Publication date: 1997-10-01
• DOI: 10.1002/art.1780401011
• EISSN: 1529-0131
• ISSN: 0004-3591
• Language: English
• Keywords: Genes, T-Cell Receptor beta; Lod Score; Humans; Microsatellite Repeats; Chromosome Mapping; Alleles; Genes, T-Cell Receptor alpha; Genetic Linkage; Arthritis, Rheumatoid