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T-bet is a key modulator of IL-23-driven pathogenic CD4+ T cell responses in the intestine

Abstract:

IL-23 is a key driver of pathogenic Th17 cell responses. It has been suggested that the transcription factor T-bet is required to facilitate IL-23-driven pathogenic effector functions; however, the precise role of T-bet in intestinal T cell responses remains elusive. Here, we show that T-bet expression by T cells is not required for the induction of colitis or the differentiation of pathogenic Th17 cells but modifies qualitative features of the IL-23-driven colitogenic response by negatively ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/ncomms11627

Authors


Krausgruber, T More by this author
Schiering, C More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, KIR
Harrison, OJ More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, KIR
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Funding agency for:
Chomka, A
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Funding agency for:
Powrie, FM
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Funding agency for:
Powrie, FM
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
7
Pages:
Article: 11627
Publication date:
2016
DOI:
ISSN:
2041-1723
URN:
uuid:3af68240-7a82-4be3-a85a-b5e727e33d8f
Source identifiers:
623480
Local pid:
pubs:623480

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