Journal article
Human in silico drug trials demonstrate higher accuracy than animal models in predicting clinical pro-arrhythmic cardiotoxicity
- Abstract:
-
Early prediction of cardiotoxicity is critical for drug development. Current animal models raise ethical and translational questions, and have limited accuracy in clinical risk prediction. Human-based computer models constitute a fast, cheap and potentially effective alternative to experimental assays, also facilitating translation to human. Key challenges include consideration of inter-cellular variability in drug responses and integration of computational and experimental methods in safe...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- Frontiers Media Publisher's website
- Journal:
- Frontiers in Physiology Journal website
- Volume:
- 8
- Issue:
- 668
- Pages:
- 1-15
- Publication date:
- 2017-09-12
- Acceptance date:
- 2017-08-23
- DOI:
- ISSN:
-
1664-042X
Item Description
- Keywords:
- Pubs id:
-
pubs:725785
- UUID:
-
uuid:3ae928e2-7a14-41ad-a0e0-8e809139a853
- Local pid:
- pubs:725785
- Source identifiers:
-
725785
- Deposit date:
- 2017-09-07
Terms of use
- Copyright holder:
- © 2017 Passini, et al
- Copyright date:
- 2017
- Notes:
- This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Licence:
- CC Attribution (CC BY)
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