Journal article
Transcription factor Wilms' tumor 1 regulates developmental RNAs through 3' UTR interaction.
- Abstract:
-
Wilms' tumor 1 (WT1) is essential for the development and homeostasis of multiple mesodermal tissues. Despite evidence for post-transcriptional roles, no endogenous WT1 target RNAs exist. Using RNA immunoprecipitation and UV cross-linking, we show that WT1 binds preferentially to 3' untranslated regions (UTRs) of developmental targets. These target mRNAs are down-regulated upon WT1 depletion in cell culture and developing kidney mesenchyme. Wt1 deletion leads to rapid turnover of specific mRN...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Bibliographic Details
- Publisher:
- Cold Spring Harbor Laboratory Press Publisher's website
- Journal:
- Genes & Development Journal website
- Volume:
- 31
- Issue:
- 4
- Pages:
- 347-352
- Publication date:
- 2017-03-01
- Acceptance date:
- 2017-02-15
- DOI:
- ISSN:
-
1549-5477
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:687048
- UUID:
-
uuid:3ae89b4e-d8f4-4188-bcf9-81e48075fa89
- Local pid:
- pubs:687048
- Source identifiers:
-
687048
- Deposit date:
- 2017-03-30
Terms of use
- Copyright holder:
- Bharathavikru et al
- Copyright date:
- 2017
- Notes:
- © 2017 Bharathavikru et al. This article, published in Genes & Development, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/
- Licence:
- CC Attribution (CC BY)
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